Published Paper Details:

Punica granatum is an extremely significant medicinal plant with commercial significance and is known for its antioxidant potential. The pericarp is a leftover unwanted part of the Punica granatum fruit that has been reported to have several medicinal uses in traditional medicine. This study focuses on analyzing the antibacterial potential of the pericarp extracts and its synergistic antibiotic effect with some beta lactum antibiotics against methicillin-resstant Staphylococcus aureus(MRSA). The antibacterial actions of water extract of dried out Punica granatum pericarps were tested against MRSA strains by agar well diffusion method. The pericarp extract sterilized by bacterial filter proved advanced inhibitory outcome against the MRSA strains. Then the pericarp extract is combined with beta lactum antibiotics such as cephalothin, cloxacillin, ofloxacin and cefoxitin. Cephalothin and ofloxacin are effective against MRSA strains individually and shows synergistic effect with Punica granatum fruit pericarp extracts. But cloxacillin and cefoxitin, are not effective against MRSA strains individually but shows synergistic effect when combined with fruit pericarp extracts. The synergistic effect of antibiotic is assessed using Checkerboard Assay method.