Published Paper Details:

Periodontal therapy aims to regenerate the lost periodontal tissues caused by periodontitis. Periodontal regeneration is a multifactorial process and requires a multi?dependent sequence of biological events, including cell?adhesion, migration, proliferation, and differentiation. Several bone graft materials have been used in the treatment of infrabony defects, but complete and predictable reconstruction of periodontal tissues is still difficult to obtain. The reason is that periodontium, once damaged has a limited capacity for regeneration. Demineralized freeze?dried bone allograft (DFDBA) has been histologically proven to be the material of choice for regeneration. However, platelet?rich fibrin (PRF) has been said to have several properties that aid in healing and regeneration. When mixed with the bone graft, PRF fragments serve as a biological connector between bone particles. Moreover, the gradual release of cytokines plays a significant role in the self?regulation of inflammatory and infectious phenomena within the grafted material. Therefore, a combination of PRF and DFDBA demonstrated better results in probing pocket depth reduction and clinical attachment gain in a various studies. In this case report, an additional clinical outcome of Combination of DFDBA with PRF in the treatment of periodontal intrabony defect was seen.