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Introduction: Adolescent is the period of development between the onset of puberty and adulthood. It usually begins from 10 years and extends up to 19 years (WHO). The high level of female mortality in the age of 15-19 years would suggest maternal mortality among young teenage mothers. To meet the goal of healthy people by 2010 there is need to make adolescent girls aware regarding the healthy lifestyle practices. The present study was conducted to evaluate the effectiveness of computer based teaching module in terms of gain in knowledge score among adolescent school going girls. Methods: Forty(40)Adolescent school going girls studying in 8thand 9thstandard at M P Birla Foundation of Higher secondary school, Kolkata in 2010 were selected by Non- probability convenience sampling technique. One group pre-test post test design was used to evaluate the effect of computer based module on knowledge level regarding healthy lifestyle practices. Data collection instruments used were Tool I � Demographic proforma , Tool II � Self Structured knowledge questionnaire on healthy lifestyle practices. Results: The obtained pre-test mean score was (18.88) whereas the post-test mean score was (24.28). The calculated �t� value was 10 at 0.05 level of significance, was significant greater than the table value indicating that the computer based teaching module was effective in increasing the knowledge of adolescent school going girls regarding healthy lifestyle practices. Conclusion :The findings of present study concluded that computer based teaching module was effective strategy for improving the knowledge of children�s on healthy lifestyle practices.