Published Paper Details:

The kinetics of oxidation of Tripelennamine hydrochloride (TPH) drug by silver(III) periodate complex (DPA) have been investigated in presence and absence of ruthenium (III) (Ru(III)) as homogeneous catalyst in aqueous alkaline medium at 298K and at constant ionic strength of 0.2 mol dm-3 spectrophotometrically. The reaction between DPA and tripelennamine hydrochloride in alkaline medium exhibits 1:1 stoichiometry in both uncatalyzed and Ru(III) catalyzed reactions (TPH: DPA). The main products was identified and confirmed as ((di-methyl-amino)-methyl)(pyridin-2-yl)-amino (phenyl) methanol by FT-IR and LC-MS spectral studies. Probable mechanisms were proposed and discussed. The activation parameters with respect to slow step of the mechanisms were computed and thermodynamic quantities were also calculated. The catalytic constant was also calculated for catalyzed reaction at different temperatures and activation parameters were computed. The active species of catalyst and oxidant have been identified.