Published Paper Details:

Abstract: BACKGROUND: Hemoglobinopathy is group of diseases characterize by abnormality all quantitative and qualitative through synthesis of hemoglobin. Hemoglobinopathies consist of sickle cell anaemia (SCA), Beta-thalassaemia Trait (BTT). In the world, they are responsible for the largest number of genetic disorders and hence are of great public health hazardous. In Yemen & India major concerned haemoglobinopathy disorders are sickle cell anaemia and ?-thalassaemia. Examination of 100 individuals showed high incidences for hemoglobin variants, HbS and Hb?T in different ethnic groups, the frequency being varies from 0% - 3% and 0% - 3% respectively. OBJECTIVE: To detection the prevalence of different hemoglobinopathies particularly beta-thalassemia trait (BTT) and sickle cell trait (SCT) and find out the incidence of anemia in them. MATERIAL AND METHODS: The present study screened 100 samples of students from Shree P.M. College of Paramedical Science and Technology Anand-Gujarat. Blood samples were initially tested by using an Automated Cell Counter (CBC), Peripheral Smear (Field Stain), Solubility Test. Samples having abnormal of morphology and MCV (?78), MCH (?28) and/or positive solubility test were comforted by Hb electrophoresis on cellulose acetate membrane(pH 8.6). Hb A2 level ?3.5% was considered as diagnostic for BTT and present HbS was considered as diagnostic for SCT. RESULT: Overall prevalence of BTT and SCT in Anand-Gujarat was 3% and 3% respectively. CONCLUSION: Study suggests that BTT and SCT is the most prevalent haemoglobinopathy in Gujarat therefore we have to do screening before marriage.