Published Paper Details:

Gabapentin is an anti-epileptic drug used in the treatment of Epilepsy. It is a water soluble drug with bioavailability of 100% and plasma half-life 5 to 7 hrs. Gabapentin tablets with various superdisintegrants were developed as oral drug delivery systems to enhance safety, efficacy of the drug molecule and to achieve better patient compliance. In the present investigation, Gabapentin tablets were formulated by wet granulation by incorporating various concentrations of superdisintegrants. The in vitro studies indicated that the drug release of optimized formulations viz. Trail 1, 2, and 3 exhibited the rank order of Trail 3 < Trail 1< Trail 2 (90.73< 98.4 < 98.63 ).Trail 1 formulation showed sufficient rheological and tableting parameters with high release rate 98.63%. Hence it could be considered as the optimized wet granulated tablet formulation with crospovidone IG (3.3%) exhibited desired immediate drug release property.