Published Paper Details:

Anticancer agents are associated with a plethora of side effects. Individual agent, within each category, has its own set of adverse reactions based on specific mechanism which in turn cause patient incompliance and deterioration of the quality of life. Among the different adverse reactions, the major one is drugs targeting the DNA, where there is an excessive production of reactive oxygen species (ROS) and subsequent buildup of oxidative stress. Several dietary supplements have been proposed by different researchers to curb these undesired side effects, amongst which antioxidants have gained increasing popularity as an adjuvant in chemotherapy.Cancer patients received chemotherapy may develop various kidney lesions that impair their life style, immediate survival as well as limit the adequate treatment of the underlying malignant process.The side effects associated with anticancer drugs are vomiting, stomatitis, diarrhea,desquamation of skin, alopecia, bone marrow depression, hepatotoxicity, ototoxicity, nephrotoxicity, cardiotoxicity and many more. There are many mechanisms developed to describe the consequences of drug toxicity. One of them is lipid peroxidation. Peroxidation of lipid results in progressive deterioration of membrane structure and loss of proper functioning of cell in the presence of oxygen free radicals. All drugs are required to cross the omnipresent membrane to produce desired pharmacological action. The drugs may cause perceptible or detectable changes in the lipid profile while crossing the membrane phospholipids. So, drugs are the potential candidates to initiate lipid peroxidation. As lipid peroxidation is one of the reasons of drug toxicity, this article is a review of anticancer drugs that have the capacity to induce lipid peroxidation as a basis of adverse effects and significances of antioxidant as a suppressor of anticancer drug-induced lipid peroxidation.