Published Paper Details:

Innate immune components found in fish epidermal mucus are released by globlet cells, which serve as a barrier between the fish and its local habitat and offer the first line of defense against many harmful bacteria. Microbe trapping and sloughing is one of mucus' primary roles. Innate immunity is provided by a variety of substances found in mucus, including lysozymes, lectins, proteases, and antimicrobial peptides (AMPs). A range of pathogens were susceptible to the antibacterial action of the AMPs released by epidermal mucus cells. Furthermore, mucosal lysozyme was observed to have strong bacteriolytic activity, whereas several proteases discovered in fish skin mucus have the ability to eliminate infections by either cleaving their protein or by inducing an immune response. Lectins are another type of mucosal agglutinin that have a variety of functions in innate immunity, including complement activation and opsonization. Fish's epidermal mucus, which is shown to be relatively temperature independent, offers an inbuilt, quick-acting, non-specific defense. The current review's objective is to give a thorough understanding of the many elements of epidermal mucus, such as AMPs, proteases, and lysozymes, as well as how they work against infections.