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Based on the concept of green chemistry, Co(II) and Zn(II) complexes of Schiff base ligands derived from 4,6-dimethoxysalicylaldehyde and glycine have been synthesized by solid-solid reaction at room temperature and characterized by elemental analyses, IR, TGA and conductivity measurements. The results indicate that the complexes are non-electrolyte in nature and are stable in air but decomposes on heating. INTRODUCTION Schiff bases and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compound and widely used for industrial purposes and also exhibit a broad range of biological activities.[1] Development of new chemotherapeutic Schiff bases and their metal complexes is now attracting the attention of medical chemists.[2] In the last decade, Schiff base ligands have received more attention mainly because of their wide applications in the field of synthesis and catalysis.[3] The attraction is still growing, such that a considerable research effort is today devoted to the synthesis of new Schiff base complexes with transition and main group metal ions to further develop application in both catalysis and material chemistry.[3] Amino acids constitute the building blocks of proteins and are chemical species indispensable for performing a huge number of biological functions. Amino acids and their derivative are extensively studied as typical N,O- donor ligands. The coordination compounds of amino acids also show good antimicrobial activities towards various microorganisms.[4] The use of Schiff bases as ligands in the formation of transition-metal complexes had been extensively studied, but the Schiff base ligands and its complexes were previously synthesized in some solvent and most synthetic methods were performed in ethanol or methanol solution.[5] This method had the disadvantages of long response time, the use of a large amount of solvents, environment pollution and low yield. Solid-solid chemical reaction at room temperature is the method used in a wide range of methods for the preparation of some compounds, and the method has a high rate and selectivity. Based on the concept of green chemistry, in this study cobalt(II) and zinc(II) complexes of the glycine- 4,6-dimethoxysalicylaldehyde Schiff base ligand have been synthesized and characterized.