Published Paper Details:

A lot of evidence suggests that cancer stem cells within a solid tumour initiate and sustain tumour growth and are quiescent even after therapeutic intervention by anti-cancer drugs. Several flavonoids interfere in cancer-stem cell-related pathways and therefore offer a promising approach for prevention. Quercetin is one such flavonoid with wide spectrum therapeutic effects. Potential mechanisms for quercetin in preventing cancer stem cells include antioxidant, anti-inflammation as well as the modulation of multiple molecular events involved in carcinogenesis. Synthesis of quercetin and peptide-based nanoparticles to further increase the efficacy of a promising nutraceutical. It can be used as a chemical template for combinatorial synthesis. Molecular targets can be identified. With the molecular targets of quercetin being known, it may be possible to develop more refined chemicals that specifically target those commonly shared sites. Synergistic effect: with the understanding of the molecular action of quercetin, the possible synergistic effects on chemo-prevention by using quercetin. In the present study, an attempt was made to synthesize quercetin encapsulated nanoparticle for target drug delivery systems and to try against various cancer stem cell lines.