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Nanoparticles have many characteristics that make them suitable for biological and medical applications. (Farthkooni et al., 2016). Nanotoxicology is a branch of bionanoscience which deals with the study and application of the toxicity of nanomaterials. (Buzea et al., 2007) Titanium dioxide nanoparticles can be used in paint production, cosmetics, ceramic production and numerous other applications like in water and sewage industries and many other industries because of its unique properties.( Mahdieh et al., 2015). A dose of 0.5 mg/cm2 and 2.0 mg/cm2was applied on 2 cm2 area of skin for 15 and 30 days. The result of present study indicate a significant hemoglobin levels, Hematocrit values, Total erythrocyte (RBC) and total leukocyte (WBC) counts, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC).MCV, MCH and MCHC percentage increased inhigh dose group only at 30 days of treatment periodHemoglobin levels, hematocrit values, RBC and WBC decreased in high dose group only at 30 days of treatment period. Platelet count increased in high dose group for 30 days treatment period. Thus the result of the study suggest dermal administration of titanium dioxide nanoparticles have adverse effect on the hematological parameters of mice. And biochemical changes of liver Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), and Alkaline Phosphatase (ALP) increased in high dose group for 30 days treatment period.