Published Paper Details:

Context: One of the leading causes of death in India is severe hepatic dysfunction. The primary goal of this study is to determine whether the polyherbal combination of chosen fruit peel extracts and hepatoprotective efficacy. Environment and Design: 1. With CCl4, induce hepatotoxicity 2. Investigation of the PHM and hepatoprotective properties of certain peel extracts. 3 Calculating different enzymes to determine liver function. Materials and Procedures After inducing hepatotoxicity, male Wistar albino rats (180-200 g) were separated into 12 groups and treated with PHM and specific extracts. Blood and liver samples were then taken and analysed on the 14th day. The experimental findings were reported as the mean of the statistical analysis (SEM). ANOVA was applied to the data where appropriate.Results and Discussion: All the selected plant extracts and PHM shown to prevent the leakage of SGOT, SGPT, and ALP in CCl4 induced hepatotoxicity. The order of potency was PHM>APMP>APCM>APMI>APAC. The APMP was the better hepatoprotective among the selected plant extracts. The activities might be due to the conditioning of hepatocytes by protecting the integrity of the membrane from CCl4 induced leakage of serum markers into circulation. All the selected plant extracts and PHM shown to revert back the SOD, CAT and GSH to the normal values in CCl4 induced rats in a dose dependent manner in liver homogenates.