Published Paper Details:

Chronic renal failure (CRF) is a growing problem worldwide leading to increasing incidence of life threatening complications or death. Over 1.1 million patients are to have renal failure worldwide with and annual increase at a rate of 70%. CKD in India is an important public health problem. The main contributing factors for high prevalence of CKD in India are hypertension and diabetes mellitus. Kidneys are those vital organs of the body responsible for diverse body function. Chronic Kidney Disease (CKD) is a condition characterized by permanent and significant loss of the glomerular filtration rate (GFR). The main stay of treatment in this condition is renal replacement therapy which includes both kidney transplantation and dialysis (Hemodialysis and peritoneal dialysis). In hemodialysis, anticoagulant is necessary to prevent blood clots within the extracorporeal circuit. Prothrombin time (PT) and activated partial thromboplastin time (APTT) are screening tests for extrinsic, intrinsic and common pathway clotting factors. The aim of the study was investigating the coagulation profile pre and post hemodialysis in CKD patients compared to normal control.