Published Paper Details:

ABSTRACT: Background: Acute ischemic stroke describes a Stroke is often referred to as a brain attack or "cerebrovascular Accident (CVA). A clot blocks a blood vessel that delivers oxygen and nutrients to the brain or bursts (or ruptures), resulting in a stroke. When this happens, brain cells in that location cannot get the blood (or oxygen) they need and perish. Alteplase and Tenecteplase are thrombolytic drugs used for ischemic stroke. Alteplase converts fibrinogen to the proteolytic enzyme plasmin, which lysis fibrin as well as fibrinogen Tenecteplase converts plasminogen to plasmin is increased relative to its conversion in the absence of fibrin. Methods: The study was carried out on 20 patients with AIS. The study was conducted by categorizing them into two groups, 10 patients were treated with Alteplase, and 10 patients were treated with Tenecteplase. The efficacy of Alteplase and Tenecteplase is assessed by using NIHSS and MRS. Health-related QOL of Alteplase and Tenecteplase was assessed using an SS-QOL questionnaire in patients with AIS. Anxiety and depression are assessed by HADS. The cost of both drugs is compared. Result: By using NIHSS and MRS it is assessed that Tenecteplase is more effective than Alteplase. The QOL in Tenecteplase patient show significant change as compared to Alteplase.