Published Paper Details:

Transdermal drug delivery system (TDDDS), commonly referred to as "patches", are medication dosage forms intended to disperse a therapeutically adequate dose of medication across the skin of patient. It is necessary to consider the complete morphological, biophysical, and physicochemical characteristics of the skin in order to transfer medical substance through the skin of humans for systemic effects. By improving patient compliance and avoiding first pass metabolism, respectively, transdermal administration offers a competitive advantage over injectables and oral methods. Transdermal delivery not only allows for continuous infusion of medication with brief biological half-lives but also avoids pulsed entrance into the systemic circulation, which frequently results in unfavourable side effects. The TDDS review papers offer insightful data on the assessment of transdermal drug delivery system. A transdermal drug delivery system stands out among the new non-invasive administration methods that have recently emerged as alternatives to traditional needle injection because of its low rate of patient rejection, exceptional ease of administration, and exceptional patient convenience and adherence. The skin care sector, including cosmetics, as well as the pharmaceutical industry may be able to use TDDS. This strategy can prevent local drug concentration builds up and non-specific drug delivery to tissue that are not the drugs target tissues because it primarily involves local administration. Nevertheless, despite countless studies being done to find a way around this bottleneck, the physicochemical characteristics of the skin translate to several challenges and limitations in transdermal distribution.