Published Paper Details:

Several obstacles must be overcome for oral drug delivery systems in order to sustain drug release and prolong the time the medication remains in the gastrointestinal tract until it has been completely ingested. After a certain amount of time, fully released When the stomach is empty, a process known as gastric emptying takes place. It could be quite helpful for athletes who are experiencing gastrointestinal issues. There is a window for nutrient absorption in the upper small intestine. Drugs that are poorly soluble or unstable in intestinal fluids might benefit greatly from floating microspheres that improve drug retention and enable prolonged action in the stomach. Floating drug delivery systems (FDDS) float in the stomach for a long time because of their lower bulk density than gastric fluids. Due to the possibility that floating microspheres in the stomach may lengthen a medication's retention time, the effects of the drug may remain longer. As a result, a longer drug retention time and a slower metabolism are required to assure long-term efficacy. FDDS dose forms are effective in situations of constipation and hyperactive bowel movement to elicit a significantly better reaction. Floating drug delivery systems (FDDSs) are helpful in these circumstances. They are anticipated to float on the stomach's contents for a considerable amount of time. Gastro retentive dosage forms are available in a variety of formats, such as tablets and capsules. Hollow microspheres are garnering a lot of interest due to their numerous potential uses in medicine delivery. Due to the drug substance being uniformly dispersed throughout the stomach juice, this prevents the drug from being released too soon. This review's objective is to examine floating microspheres approach in Gastro-retentive Drug Delivery System