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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
Call For Paper - Volume 12 | Issue 5 | Month- May 2024
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Paper Title
A STUDY ON ANXIOLYTIC ACTIVITY OF AQUEOUS EXTRACTS OF MATRICARIA CHAMOMILLA L IN ELEVATED PLUZ MAZ APPARATUS AND LIGHT AND DARK CHAMBER IN ALBINO MICE
Authors
BILLA DURGA BHAVANI, CHAKALA SURESH BABU, CHEGUDI GOPICHANDA, KONDI REDDY MEENAKSHI, GOLLA SUJATHA
Keywords
Anxiolytic-like effect, Matricaria chamomilla L, Elevated plus maze, Light and dark chamber, Diazepam.
Abstract
This study was performed to investigate the anxiolytic effects of alcoholic extract of Matricaria chamomilla L (AEMC) in mice using the elevated plus-maze model (EPM), light dark model and hole board test. The extract administered orally in three different doses of 250mg/kg, 500mg/kg and 750mg/kg, were able to increase the time spent and the number of arm entries in the open arms of the elevated plus-maze, also increases the time spent by mice in the illuminated side of the light and dark test, dose of 500mg/kg and 750mg/kg showed more significant increase in nose poking and decrease locomotion in hole board test, in comparison with control animals. This effect was comparable to that of the diazepam (1.0mg/kg p.o.). These results indicate that AEMC is an effective anxiolytic agent.
IJCRT's Publication Details
Unique Identification Number - IJCRT2303171
Paper ID - 232075
Page Number(s) - b549-b559
Pubished in - Volume 11 | Issue 3 | March 2023
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
BILLA DURGA BHAVANI, CHAKALA SURESH BABU, CHEGUDI GOPICHANDA, KONDI REDDY MEENAKSHI, GOLLA SUJATHA, "A STUDY ON ANXIOLYTIC ACTIVITY OF AQUEOUS EXTRACTS OF MATRICARIA CHAMOMILLA L IN ELEVATED PLUZ MAZ APPARATUS AND LIGHT AND DARK CHAMBER IN ALBINO MICE", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.11, Issue 3, pp.b549-b559, March 2023, Available at :http://www.ijcrt.org/papers/IJCRT2303171.pdf
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Submit Manuscript Online Impact Factor: 7.97 Review Results : Within 02-03 Days Paper Publication : Within 02-03 Days
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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