Published Paper Details:

ABSTRACT: Hypertension is the most common cause of mortality in both developed and developmental countries. Experimental animal models of hypertension have become a valuable tool for providing information on etiology, pathophysiology, and complications of the diseases and on the efficacy of various drugs and compounds used in the therapy. Compared to human model, animal model is easily manageable, as compounding effects of dietary and environmental factor can be controlled. Cardiac tissue and blood samples can be taken for thorough experimental and bimolecular review from such animal models. An animal model is often resolute by the research object, as well as financial and technical factors. A complete understanding of animal model used and complete analysis must be validated so that the data can be extrapolated to humans. Animal models of hypertension are invaluable in improving our understanding of cardiovascular diseases and developing new pharmacological therapies. Among this the most studied model is SHR (spontaneous hypertension in rat) model. SHR was established and discovered as a result of the deliberate inbreeding of rats with the greatest blood pressure and the development of a novel technique for monitoring rat blood pressure.