Published Paper Details:

ABSTRACT: Baclofen is a centrally acting muscle relaxant. It relieves the spasm, cramping and tightness of muscles from multiple sclerosis, spinal cord injuries or other spinal cord diseases. In the present research work fast dissolving tablets of Baclofen were prepared by solid dispersion and direct compression methods. The concept of formulating fast dissolving tablets containing Baclofen offer a suitable and practical approach in serving the desired objective of faster disintegration and dissolution characteristic with increase bioavailability. Fast dissolving tablets of Baclofen were prepared by using various techniques like solid dispersion and direct compression. Prepared tablets were subjected to different evaluation parameters such as hardness, friability, weight variation, drug content uniformity, wetting time, water absorption ratio, in vitro disintegration time, in vitro dissolution studies and stability studies. Results revealed that all formulations have acceptable physical parameters.