Published Paper Details:

Imidazopyridine derivatives are a proton pump inhibitor that reduces gastric acid secretion and has been successfully used to heal and relieve symptoms of gastric or duodenal ulcers and gastro-esophageal reflux. It has been synthesized by an oxidation of sulfide produced from a substitution reaction between 2-mercaptobenzimidazole and pyridine derivatives. The transformation of sulfide into sulfinyl has been generally carried out with peroxyacid such as mCPBA. The method for optical resolution includes fractional recrystallisation. The fractional recrystallisation method includes a method in which a salt is formed between a racemate and an optically active compound [eg. (+)-Mandellic acid, (-)-Mandellic acid] and salt is separated by fractional recrystallisation etc. and if desired subjected to neutralization process to give a free optical isomer. The chiral column method includes a method in which a racemate or a salt is applied to a column for optical isomer separation. In High performance liquid chromatography for example optical isomer are separated by adding the racemate to a chiral column (such as Daicel series) and eluting in water a buffer (for example, a phosphate), an organic solvent (for example, hexane, ethanol, methanol, isopropanol, acetonitrile, triethylamine or mixture thereof) or mixture of the foregoing.