Published Paper Details:

sustained release bilayer tablet containing metformin and glimeperide in which metformin is in the form of sustained release layer and Glimeperide is in the form of immediate release layer gives fast release. The aim and objective of present study is to design and prepare oral dosage form able to deliver a first impulse of the dose in the shorten time possible and a second fraction of dose in the prolonged time at a constant rate. This combination of drugs used in Diabetes Mellitus type 2 which shows potent effect. Metformin tablet were prepared by using tablet compression technique. different grades of HPMC were used. HPMC used as a matrix forming polymer for the metformin layer enables drug release for up to 9-10hour. Glimeperide tablet are prepared by using solvent evaporation method ofsolid dispersion technique is PEG6000.The formulated Metformin Hydrochloride & Glimeperide tablets were evaluated for thickness, hardness, weight variation, friability, drug contents & in vitro drug release .