Published Paper Details:

Sickle cell disease is a chronic disease characterized by progressive multiorgan failure, particularly involving the liver and kidney. Chronic renal disease occurs in 25% of older adults and results in 50% of their deaths. Patients with sickle cell disease have increased mortality rates from renal failure compared with non sickle cell patients. Sickle cell disease (SCD) produces many structural and functional abnormalities in the kidney, including glomerular abnormalities.. Reduction of renal concentration capacity, urinary acidification, impaired potassium metabolism often observed in these patients. Glomerular filtration rate exceed the normal value in children and adults. Proteinuria is prevalent in 25% cases, microalbuminuria was seen among the Hb SS patients than in Hb AS which is important marker of glomerular injury with Hb SS patients which is associated with reduce creatinine clearance. In the present study we have examined prevalence of renal dysfunction in the individuals with Hb SS and Hb AS. In addition we have tried to establish the correlation between kidney dysfunction and duration of disease.