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ABSTRACT A Retrospective Study Of Isolated Sphenoid Sinusitis On Computed Tomography Background: Isolated sphenoid sinusitis is a rare disease of inflammatory and neoplastic origin. Diagnosis and treatment of isolated sphenoid sinusitis is difficult due to its non-specific symptoms and its late presentation. It is often overlooked due to its remote location. Materials and Methods: A retrospective study was conducted from December 2018 to November 2022 in MVJ Medical College by a computer-assisted search of all the reports of CT scans performed with clinical symptoms of sinusitis namely headache and nasal obstruction to detect the presence of isolated sphenoid sinus opacification, mucosal thickening and its complications. A total of 55 cases of isolated sphenoid disease were identified. Results: We identi?ed 55 cases of isolated sphenoid disease of which 27 were females and 28 were males. 7 patients were in less than 20 year age group, 26 patients in 21-40 year group, 15 patients in 41-60 year age group and 7 patients in older than 60 years. Isolated acute sphenoid sinusitis with air-fluid level was seen in 25 cases. Isolated chronic sphenoid sinusitis was seen in 30 cases. Incidentally, asymptomatic isolated sphenoid opacification was seen in 8 cases. Neuro-ophthalmic complication was noted in one case. Conclusion: Opacification of paranasal sinuses is frequently seen. However isolated opacification of the sphenoid sinus is uncommon with low clinical suspicion. Therefore, imaging studies like Computed Tomography is necessary for the assessment of isolated sphenoid sinusitis for its diagnosis and early detection of complications.