Published Paper Details:

ABSTRACT Wet granulation, direct compression, or dispersion of solid particles within solid particles within a porous matrix created by employing various polymers, such as polymethyl methacrylate (PMMA), polyglycolic acid, HPMC, etc., are the main methods used to create sustained release matrix tablets. The matrix regulates the drug's rate of release. Release inhibitors, such as HPMC, can help with sustained release, making them a key excipient in the formulation. The process involves directly compressing a mixture of the medicine, the retardant material, and the additives to create a tablet with the drug embedded in the matrix core of the retardant. Granulation may also be done before compression. The matrices employed could be mineral, hydrophilic, hydrophobic, or biodegradable in nature.Studies of in-vitro dissolution can be used to determine the medication release rate. Ambroxol HCl, nateglinide, and other medications have been created as sustained release matrix tablets. Thus, by reducing the total dose and dosage schedule, sustained release matrix tablets can provide improved patient compliance, which is very beneficial for the treatment of chronic diseases.