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  Published Paper Details:

  Paper Title

PHOSPHODIESTERASE 5 INHIBITORS: A REVIEW OF ANALYTICAL METHODS

  Authors

  Mr. Mayur S. Jain,  Dr. Shailesh K.Koradia,  Dr. Shashikant D. Barhate

  Keywords

A phosphodiesterase type 5 inhibitor (PDE5 inhibitor, Sildenafil, tadalafil, Avanafil, mirodenafil, udenafil and lodenafil, Zaprinast

  Abstract


A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug which works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues. These drugs dilate the corpora cavernosa of the penis, facilitating erection with sexual stimulation, and are used in the treatment of erectile dysfunction (ED). Sildenafil was the first effective oral treatment available for ED. Because PDE5 is also present in the smooth muscle of the walls of the arterioles within the lungs, two PDE5 inhibitors, sildenafil and tadalafil, are FDA-approved for the treatment of pulmonary hypertension. As of 2019, the wider cardiovascular benefits of PDE5 inhibitors are being appreciated

  IJCRT's Publication Details

  Unique Identification Number - IJCRT2211430

  Paper ID - 227586

  Page Number(s) - d733-d742

  Pubished in - Volume 10 | Issue 11 | November 2022

  DOI (Digital Object Identifier) -   

  Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882

  E-ISSN Number - 2320-2882

  Cite this article

  Mr. Mayur S. Jain,  Dr. Shailesh K.Koradia,  Dr. Shashikant D. Barhate,   "PHOSPHODIESTERASE 5 INHIBITORS: A REVIEW OF ANALYTICAL METHODS", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.10, Issue 11, pp.d733-d742, November 2022, Available at :http://www.ijcrt.org/papers/IJCRT2211430.pdf

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ISSN: 2320-2882
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Journal Starting Year (ESTD) : 2013
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ISSN and 7.97 Impact Factor Details


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ISSN: 2320-2882
Impact Factor: 7.97 and ISSN APPROVED
Journal Starting Year (ESTD) : 2013
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