Published Paper Details:

Incompatibility is defined as a change resulting and an undesirable product is formed, which may affect the safety, efficacy, appearance and stability of the pharmaceutical product. Pharmaceutical incompatibility is a combination of ingredients in which, because of the interaction of medicinal substances between themselves or with excipients, their physical and chemical properties change and thus the stability and effect of the medicine. It is of three types. It includes physical, chemical and therapeutic incompatibilities. The below described article gives the detailed information about the types, causes and how to overcome these types of incompatibilities. The given information of the problem of pharmaceutical incompatibilities, in our opinion, will increase the professional knowledge of pharmacists about the physical phenomena and chemical interactions that may occur in dosage forms, types of pharmacological incompatibilities and will guide them in practical activities in preparation of extemporaneous medicines in different dosage forms.