Published Paper Details:

Enhydra fluctuans (Family: Asteraceae) a hydrophytic plant known as marsh herb growing throughout the year and adequately available in north east region of India. This plant is used as folk medicine for its diversified medicinal benefits. Current experimentation was performed to scientifically validate the antiulcer potential of the plant extract by using rat ulcer models (pylorus ligation rat ulcer model and ethanol induced ulcer model).Based upon result of acute toxicity study two doses (low dose 200mg/kg and high dose 400mg/kg) of methanol extracts of aerial part of the plant were selected for evaluation. The route of administration of the extract was oral for 7 days. Various biochemical parameters (total and free acidity, protein, pepsin, carbohydrate) were observed along with microscopic evaluation of rat stomach. The result revealed that with higher dose of methanol extract of Enhydra fluctuans reduction of gastric ulcer can be achieved and was evident in both the rat ulcer model. The outcome of current study holds up the folkloric claim of the plant for treatment in case of peptic ulcer disease hence suggestive of becoming a very potent pharmacological agent against the disease.