Published Paper Details:

Complexes of Mn(II) and Fe(III) with trimethoprim Schiff base ligands,HL1 and HL2 derived from salicyldehyde and benzaldehyde were synthesized and investigated. The complexes have been characterized using metal analysis, molar conductance, FT-IR, UV-Vis and melting point, Infrared studies have shown that Mn(II) and Fe(III) ions coordinated to the ligands through azomethine nitrogen of the pyrimidine in all the complexes. The ability of these complexes to inhibit the growth of pathogenic microorganism such as: Staplococcus pyogenes, Bacillus subtilis (as Gram positive bacteria), Corynaebacterium specie, Shigella dysentriae (as Gram negative bacteria) and Candida albicans (as Fungus species) were compared with the parent drug (trimethoprim).The results of antimicrobial activity have revealed that the complexes are more potent as compared to the parent drug. The MIC and MBC results further confirmed that Fe(III) complexes posses enhanced inhibition against both Gram positive and Gram negative isolates.