Published Paper Details:

Abstract :- The main aim of this research is to Formulation and characterization of Lumefantrine co-crystal with improved physicochemical and dissolution properties. The choice of correct solvent system is important for the synthesis of co-crystals which requires the knowledge of solution complexation.The present work to enhance solubility by modifying the crystal habit and enhance stability. Lumefantrine is a BCS class II drug .Standard solution of Lumefantrine in Methanol was prepared in 100?g/ml.Absorbance was measured at 234 nm. To characterize co-crystals for morphology and surface topography by Scanning Electron Microscopy, for crystal polymorphism study by Differential Scanning calorimetry (DSC) and for crystanality by Powder X-ray diffraction. Preparation of co-crystals by solvent evaporation method. Saccharin, Croscarmellose sodium, Avicel 102, PVP K30 , Magnesium stearate these excipients was used for formulation.Evaluation and optimization of co-crystals was done by different methods.