Published Paper Details:

Microsponge can be effectively incorporated into topical drug delivery systems for dosage form retention on skin, as well as use for oral drug delivery using bioerodible polymers. Entrapment of ingredients in microsponge drug delivery systems is thought to contribute to reduced side effects, improved stability, reduced systemic exposure and minimise local cutaneous reactions, increased elegance, and enhanced formulation flexibility. The Microsponge Delivery System is a novel technology for the controlled release of topical agents that consists of macroporous beads loaded with active agent that are typically 10-25 microns in diameter. When applied to the skin, the microsponge releases its active ingredient in response to time and other stimuli (rubbing, temperature, pH, etc). Numerous studies have shown that microsponge systems are non-irritating, non-mutagenic, non-allergenic, and non-toxic. Microsponges delivery technology is currently used in cosmetics, OTC skin care, sunscreens, and prescription products. This review focuses on microsponge preparation, characterization, and application.