Published Paper Details:

Onychomycosis is the most common disorder affecting the nail unit and accounts for at least 50% of all nail diseases. Nail is an important segment for effective treatment of onychomycosis and consists of a network of keratin proteins. Oleic acid, Tween 80, and Propylene glycol were selected as the oil, surfactant, and co-surfactant respectively for the construction of the phase diagram. 2:1 smix ratio was finalized due to larger nanoemulsion region in pseudo ternary phase diagram. The nanoemulsion formulations were prepared by using ultrasonication method. Luliconazole Nanoemulsions were characterized by droplet size, zeta potential, pH, viscosity, refractive index, drug content. The optimized batch of nanoemulsion was converted into nanoemulsion gel by using combination of 0.5%w/w Carbopol 934 and 0.5%w/w xanthan gum. Nanoemulsion gel was evaluated for pH, spreadability, extrudability, rheological study and in vitro drug release study.