Published Paper Details:

Background: Medicinal plants play important roles to treat various ailments. Erythrina variegata is one of the folklore plants frequently used for wound treatments. Nevertheless, pharmacological investigations have not been performed to substantiate activity of the plant extract in wound healing. Hence, this study provides Pharmacological evaluation of the wound healing activity of leaves of Erythrina variegata on experimental animals. Materials And Methods: The leaves extraction was carried out using 80% ethanol. The leaves extract was prepared in 5% (w/w) and 10% (w/w) extract ointments. An acute dermal toxicity study of the extract was conducted in female mice by observing the signs of toxicity. Then 5% and 10% (w/w) ointments of the extract were applied topically to investigate their wound healing activity using excision and incision wound models in Swiss albino mice. Parameters such as wound contraction, Period of epithelialisation, and tensile strength were determined. Results: In acute dermal toxicity test the application of 10% (w/w) ointment formulation the site of application no signs of dermal toxicity were observed in mice. Both 5% and 10% (w/w) ointments significantly reduced period of epithelialization and increased wound contraction rate and tensile strength. Conclusion: The results of this study showed that both 5% w/w and 10% w/w of 80% ethanolic leaves extract of E. variegata possesses wound healing activities.