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Abstract: 1. History: Digitalis is the plant that is the origin of Europe, Western Asia, and Northwestern Africa. Digitalis is one of the main herbal medicines which is used as remedies by the various ancient Romans. It is the best drug of choice and its use for the treatment of heart failure has been traced back to 10th century Europe, digitalis was not widely used for this indication until its scientific investigation by British physician William Withering in the late 1700s. For most of the 1800s, digitalis was used to treat a wide variety of diseases and disorders. In 1875, German chemist Oswald Schmiedeberg first isolated pure digitoxin from digitalis, leading others to extract and identify other glycosides from various species of digitalis. In 1957, digoxin was isolated from Digitalis. lanata and is now a major cardiac glycoside marketed in tablet form. Digitalis was admitted into the first edition of the Pharmacopeia of the United States (1820) and is currently recognized by all major pharmacopeia. In South America, preparations of the powdered leaves are used to relieve asthma, as sedatives, and as diuretic/cardiotonic. In India, an ointment containing digitalis glycosides is used to treat wounds and burns. Belcastro 2002, Feussner 2010, Morton 1997. 2. Origin: Digitalis is the drug classified under the class of cardiac Glycoside. This drug is approved by the FDA in the year of 1954. They coined Digitalis as a foxglove plant known as the digitalis plant. The whole study of Digitalis is done by the scientist William Withering, he is an English Physician and Botanist in the years from the 1780s. 3. Keywords: Digitalis, Heart Disease, Digitoxins, Cardiac Glycoside, foxglove, Cardiotonic. 4. Cardiac Glycosides: These are an important class of naturally occurring drugs. The action of this drug includes both beneficial and toxic effects on the heart. Cardio-active Glycosides are the group of steroidal glycosides are act as cardiotonic agents with various properties such as are amorphous, powder form, soluble in water, having a bitter taste, and insoluble in an organic compound, they are very toxic compounds when consumed in the large dose and they are odorless. Stability as acid hydrolysis, enzymatic hydrolysis.