Published Paper Details:

Objective: Simple, sensitive, precise and accurate method for quantitative determination of drugs viz., CetirizineDihydrochloride (CTZ), Imatinib Mesylate (ITM), Voriconazole (VCZ) have been developed. Method: This method depends upon the oxidation of the drugs by a known excess N-Bromosuccinimide (NBS) in Hydrochloric acid medium and subsequent determination of unreacted NBS by using Rhodamine-B dye. Results: The quantity of the drug present in commercial tablets with no interference of the excipients was assessed by applying this proposed method. This method has been validated in terms of LOD, LOQ, precision, accuracy, %RSD, robustness and ruggedness. Factors affecting the absorbance viz., time of reaction and concentration of Hydrochloric acid are optimized. The presence of excipients has also been examined and found no effect. The calibration curves are found effective for the assessment of pure drug and pharmaceuticals. These curves also can be applied in bulk drug and pharmaceutical industries.