Published Paper Details:

Background: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still an ongoing global health emergency. Siddha Medicine is a valuable therapeutic choice which is classically used for treating both bacterial and viral respiratory infections. Vishnu kiranthi Kudineer is a drug indicated for all the 64 types of suram mentioned in Siddha sastric literature. An attempt is made to identify the possible inhibition of the phytocomponents of Vishnu kiranthi Kudineer in inhibiting ACE2 Receptor Spike protein in SARS-CoV-2 through molecular docking studies. Methodology: In Silico molecular docking analysis was performed for phytocomponents present in the Vishnu kiranthi Kudineer formulation for targets ACE2 Receptor Spike protein, PDB - 2AJF using Autodock tool. Results: Among the 11 active Phytocompounds present in the Vishnu kiranthi Kudineer formulation, Bisabolene, Linolenic acid and Corilagin possess 100% and Gallic acid , Gingerenone A, Squalene, Allose, Piperine, Maslinic acid and Amyrin possess 50% affinity by interacting with both the core target amino acids (31 LYS and 353 LYS) present on the target which shows the promising contrivance of ACE 2 receptor inhibition. Conclusion: The phytocomponents showed possible affinity towards these targets and has the leads such as Bisabolene, Linolenic acid and Corilagin that may exerts promising inhibiting against ACE2 receptor.