Published Paper Details:

ABSTRACT Angiotensin converting enzyme 2 (ACE2) is a transmembrane protein which is considered as a receptor for spike protein binding of novel corona virus (SARS-CoV2). Since no specific medication is available to treat COVID-19, designing of new drug is important and essential. In this regard, this study was to seek potential natural compounds that can resist COVID-19 using in silico molecular docking on ACE2 proteins. Molecular docking was achieved by using the Argus lab software. Natural products are safe and easily available to treat corona virus affected patients, in the present alarming situation. The natural phytocompounds acting on spike protein of SARS-CoV2 with its human receptor ACE2 molecule were then selected from siddha medicine one of the traditional systems of India Sundaikai vattral Choornam (Solanum torvum) have valuable properties of cold, cough, tuberculosis, hepatotoxicity, cancer, etc. Results: eight potential natural anti-COVID-19 phytocompounds were selected and were evaluated for absorption, distribution, metabolism and excretion (ADME) and Lipinski rules. The content of the eleven phytocompounds from Solanum torvum were determined via a literature search. Conclusion: Solanum torvum show promise for resisting COVID-19 and are thus recommended as supplements to prevent the infection of COVID-19 during its outbreak period.