Published Paper Details:

Abstract Context: To increase the duration Lansoprazole spends in the stomach, a continuous release mechanism was developed. Objective: The influence of varied concentrations of different polymers on the creation of floating microspheres using the ionotropic gelation process. Result: Microspheres were found to be spherical in form, with a mean diameter of 456.8m, according to morphological analysis. The production of Lansoprazole loaded Microspheres was achieved through the use of appropriate experimental conditions, with the F6 batch being identified as the Optimized formulation, with a high entrapment efficiency of 86.3 percent (w/w) and a high percent cumulative drug release of 92.24 percent 24th hr, indicating that Lansoprazole loaded Microspheres have the potential for prolonged drug release. After three months of testing at 4 + 1oC and room temperature, the formulations demonstrate that they degrade faster at high temperatures. The Microsphere's optimal storage temperature, according to the findings, is a cool place.