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: Clinical Research plays major role in the health care. Now a days Clinical Research is a health care profession that gives you all information about new tests and treatments and effectiveness of that medication on human health. Clinical research is origin Form the year of 1747.The aim of this paper presentation is to give an overview about all the key concepts of research and all this information is very important for the viewers to study or to identify how the science is working and how to perform the new experiments and various research are to be done and how the drug is going to market. In clinical research, our aim to design a study which would be able to drive a valid and meaningful scientific conclusion using appropriate statistical methods. A conclusion derived from the research study is improve the health care and safety of individual results inadvertent harm to patient. Hence, this requires well designed clinical research study that rest on a string foundation of methodology and all are governed by ethical principles. The purpose of this review is to provide an overview to reader to the basic study design and all the aspects and applicability in clinical research. It was the Belmont Report that finally explicated the principle of informed consent proposed 30 years prior in the Nuremberg Code. Informed consent, now a mandatory component of clinical trials that must be signed by all study participants (with few exceptions), must clearly state. This is a research study (including an explanation of the purpose and duration; and the risks, benefits, and alternatives of the intervention), Participation is voluntary, the extent to which confidentiality will be maintain exact information for questions or concerns.