Published Paper Details:

Introduction: The upper gastrointestinal tract starts from buccal cavity and continues uptill the duodenum where the suspensory muscle demarcates between upper and lower gastrointestinal tract.Diseases of the upper gastrointestinal tract includes neoplastic and non neoplastic lesions. Upper gastrointestinal tract is a common site for neoplastic lesions, especially malignant tumors. Gastric cancer, is the fourth-most-common type of cancer and the second highest cause of death due to cancer globally. Aims & Objectives: 1. To determine the spectrum of histopathological lesions both non-neoplastic and neoplastic lesions in patients undergoing upper gastrointestinal biopsy and correlate them with clinical presentation, age and sex. 2. To establish endospic biopsies as an effective tool in proper diagnosis and management of various lesions. Methodology: This was one year observational study carried out between January 2019 to January 2020 in Dhiraj Hospital. Results: In our study, 166 cases of endoscopic biopsies were studied. Peak incidence was seen in the age group of 45-65 years, with higher male predominance. Dysphagia was the most common presenting symptom. Stomach was the most common site with 46 % of incidence. Gastritis was most common type of lesion followed by adenocarcinoma. Second most common site was duodenum (29%), with duodenitis being the common presentation. Conclusions: Endoscopic biopsy permits exact diagnosis along with providing opportunity to see the lesion status and helps in deciding specific therapy. Histopathological study helps to detect mucosal lesions at an early stage like atrophy, intestinal metaplasia and dysplasia to prevent its progression into invasive cancers.