Published Paper Details:

Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers, which are biodegradable in nature and ideally having a particle size less than 200?m. This is the important approach in delivering therapeutic substance to the target site in sustained and controlled release fashion. Size of microspheres affects the rate of drug release. As size decreases, the surface area-to-volume ratio of the particle increases. Thus, for a given rate of drug diffusion through the microsphere, the rate of flux of drug out of the microsphere, per mass of formulation, will increase with decreasing particle size.Microspheres were prepared by optimizing various parameters and studying their effects on particle size as well as entrapment efficiency. It was then incorporated into a cream base to form a suitable topical drug delivery system. From the experiments, it was concluded that; as polymer amount increases, particle size and drug entrapment increase; as surfactant concentration increases, particle size and drug entrapment decreases; as stirring speed increases, particle size and entrapment decrease. Microspheres was prepared with aim to deliver the drug which passes through transdermal route as it provides quick onset of action when compared to oral route.