Published Paper Details:

The goal of this study is to formulate and evaluate Promethazine hydrochloride Oral Fast Dissolving film as a powerful antihistamines used to alleviate nausea, motion sickness, and better bioavailability in comparison with conventionally solid oral dose. This work was performed to formulate an antimigraine medication, Sumatriptan Succinate (SUM), mouth dissolving films (ODFs) to improve the comfort and compliance with older and pediatric patients for better therapeutic effectiveness. The formulation of ODFs was formerly made from Hydroxy Propyl Methyl Cellulose alongside film modifier / solubilizing agents, PVP K30 and Sodium Lauryl Sulphate (SLS). The ODFs were developed using wet film applicator techniques and their physical and mechanical characteristics were evaluated for in vitro disintegration, and in vitro. The dissolution properties were strengthened when compared with the HPMC E15 for ODFs, 13 percent (w/w) of HPMC E5. ODFs with PVP K30 and SLS provided superior dissolution properties when compared to ODFs without PVP K30 and SLS. The dissolution properties of ODFs with PVP K30 were superior as compared to ODFs with SLS. SUM MDFs have overall demonstrated strong mechanical characteristics including strength of the tensile, folding resilience, length of time and dissolution. The HPMC is an outstanding former film for the fast release of drugs. These findings indicate that the planning process for oral film dissolution. Solvent casting, semi-solid casting, hot melt extrusion, solid dispersion extrusion, rolling current assessment takes the formulation of various preparation methods and quality controls for fast oral thin film dissolving into account.