Published Paper Details:

The present study is to optimize and characterize a Nanostructured Lipid Carrier (NLC) loaded transdermal drug delivery system loaded by antifungal drug. The goal of this research is to optimize the NLCs and to study its potential for the topical delivery of Luliconazole by prolonging the drug release through the NLC transdermal gel. Preformultion studies for the drug and excipients studies are carried out by IR. Pre-optimization studies were carried out for the selection of suitable formulation variables from lipids, surfactant and process variables from ultrasonication time. From the selected variables, 15 NLC formulation were designed by using Solvent diffusion technique and optimized based on the impact of independent variable on dependent variables like Particle Size and percentage Entrapment Efficiency (% EE) by applying Box- Behnken design utilizing multiple linear regression method (Design expert software). The selected optimized NLC formulation was fabricated into transdermal gel. It was evaluated for viscosity, Drug content, pH, Spread ability and In vitro diffusion studies.