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On this green planet, there are uncountable plants that are considered wild/ weed/ unwanted due to lack of obvious economical value. However, these plants have adapted well to harsh conditions and thrive very well without any special attention. But, every organism created by Mother Nature has its value. Nothing is useless. Hence, these herbaceous weeds also have something valuable in their genomic constitution but they need sharp eyes and great passion to be explored scientifically in sustainable manner. In past many of the plants that were considered useless are now proven very important in terms of their phytochemicals. The wild herbs / shrubs and trees actually are the great reservoirs of novel phytochemicals and hence one aspect of biodiversity research is to conserve these precious gene pools before they become extinct. Argemone Mexicana is native to Mexico and presently prevalent yearly weed of family Papaveraceae, mainly connected with farming corps and harsh environments. It is a chief weed for numerous cash to crops in the tropical, sub-tropical and humid temperature parts of the world. The Vernacular names of this plant are Mexican prickly poppy, flowering thistly, cardo / cardosantro, etc. In India this plant is variously known as agara / bharband/ bharbhar/ brahamandandi etc. This exacting plant species is considered as a risk to healthiness. If taken with contaminated food because is causes intense itchiness, is an annoyance to the farmers.