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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
FORMULATION AND EVALUATION OF SUSTAINED RELEASE BILAYER TABLETS OF LOSARTAN POTASSIUM
Authors
Mrs. Gayatri Chinchulkar, Dr. Malik Tauheed Ahmed, Dr. Aatera Anees Ahmad, Miss. Iftesham Mohd. Jalil, Dr. Naeem Ahmed Shaikh Ibrahim, Dr. Jameel Abbas
Keywords
Bilayer Tablet of Losartan Potassium
Abstract
The aim of present study is to prepare bilayer tablets of Losartan Potassium with an immediate release and a controlled release layer. The immediate layer was prepared using super disintegrant sodium starch glycolate and controlled release layer is formulated with polymer guar-gum and HPMC K15M, individually in different concentrations and in combinations. The values of pre-compression parameters evaluated were within prescribed limits. Post compression parameters such as hardness were found to be 5.46 to 7.21 kg/cm2 sufficient enough to withstand the mechanical stress condition while handling. In all the formulations, the friability value is less 1% and meets the Indian Pharmacopoeial limits. The percentage drug content of all the tablets was found to be almost are nearer to 100%, swelling index of matrix tablets were directly proportional to the concentration of the polymer.
IJCRT's Publication Details
Unique Identification Number - IJCRT2112001
Paper ID - 213498
Page Number(s) - a1-a22
Pubished in - Volume 9 | Issue 12 | December 2021
DOI (Digital Object Identifier) -
Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Mrs. Gayatri Chinchulkar, Dr. Malik Tauheed Ahmed, Dr. Aatera Anees Ahmad, Miss. Iftesham Mohd. Jalil, Dr. Naeem Ahmed Shaikh Ibrahim, Dr. Jameel Abbas, "FORMULATION AND EVALUATION OF SUSTAINED RELEASE BILAYER TABLETS OF LOSARTAN POTASSIUM", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.9, Issue 12, pp.a1-a22, December 2021, Available at :http://www.ijcrt.org/papers/IJCRT2112001.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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