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ABSTRACT: Patient safety is a fundamental in delivering quality essential health services. Indeed, there is a clear consensus that quality health services across the world should be effective, safe and people-centered. In addition, to realize the benefits of quality health care, health services must be timely, equitable, integrated and efficient. To ensure successful implementation of patient safety strategies; clear policies, leadership capacity, data to drive safety improvements, skilled health care professionals and effective involvement of patients in their care, are all needed. OBJECTIVE: 1. To prepare and validate skill competency program on patient safety among nursing interns in experimental and control group. 2) To evaluate the effectiveness of skill competency program on patient safety in terms of knowledge and practice among nursing interns students in experimental group.3) To compare the post test knowledge and practice score on patient safety in experimental and control group. 4)To find the co- relation of post test knowledge and practice score on patient safety among nursing interns in experimental and control group. 5)To find out the association between post test score of knowledge and practice on patient safety among nursing interns with their selected demographic variables in experimental group. METHODS AND RESULT: An evaluative research approach was used in the study to determine the effectiveness of skill competency program in terms of knowledge and practice regarding patient safety among nursing interns students at selected hospitals Meerut. The research design selected for the study was Quasi-experimental nonequivalent control group pretest-post-test design. In experimental group pretest knowledge score of the nursing interns show that 0% were having excellent and good knowledge 19 were having average knowledge and 11 were having poor knowledge. In experimental group in level of knowledge, mean for pre test is 10.566 and mean for post test is 22.066. mean difference between pre test and post test is 11.499, SD difference is 0.938. In control group in level of knowledge, mean for pre test is 7.466 and mean for post test is 9, mean difference between pre test and post test is 1.534, SD difference is 0.123. There was moderate positive co-relation between post test level of knowledge and practice score in experimental group. Hence, the research hypothesis H2 was accepted and null hypothesis H02 was rejected at 0.05 level of significance. CONCLUSION: The study concluded that nursing interns student working in CSS Hospital Meerut, were having deficit knowledge and practice regarding patient safety and skill competency program was found to be an effective method to improve the knowledge and practice of nursing interns student.