Published Paper Details:

Flurbiprofen is a minimal solubility, greater permeability non-steroidal anti-inflammatory medication classified as BCS class II drug. To enhance the drug's physicochemical properties, pharmaceutical co-crystals of Flurbiprofen were made with arginine as the co-crystal former. Flurbiprofen co-crystals were successfully prepared using the solvent drop grinding process. IR spectroscopy, differential scanning calorimetry, and X-ray diffraction were used to validate the integrity and uniformity of all proposed crystal structures. When compared to pure active pharmaceutical component, co-crystals with arginine exhibited a greater powder dissolving rate (API). When compared to the pure active pharmaceutical ingredient, co-crystals of flurbiprofen with arginine demonstrated a 5.2 times gradual increase in solubility. Co-crystals are an evolving approach for modifying and enhancing physicochemical aspects of drugs to improve their medicinal effects, as per the research.