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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
Call For Paper - Volume 12 | Issue 5 | Month- May 2024
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Paper Title
SUSTAIN RELEASE BEHAVIOR OF METFORMIN HYDROCHLORIDE THROUGH INCORPORATION OF STOMACH AND INTESTINE SPECIFIC SODIUM ALGINATE BEADS
Authors
Navnath Bidgar, Dr.K.B.Burade, Dr.M.S.Charde
Keywords
Metformin hydrochloride (MH), Gum Ghatti (GG), Mucoadhesion, Sustained release, alginate beads.
Abstract
Ionic gelation was used to create sodium alginate and gum ghatti (GG) bio adhesive beads containing metformin HCl for orally usage. A 32 factorial design has been used to evaluate the effects of gum ghatti concentration and HPMC K100M concentration on the bead size (mm) and % Drug release after 12 hours (DR % ) of ionotropic ally gelled sodium alginate and gum ghatti muco-adhesive beads containing metformin HCl. CCD is utilised for this, and response surface methodology (RSM) is used. The optimized sodium alginate beads had a bead size of 1.2mm to 1.45mm and a DR of 79 % to 91 % after 12 hours. The in-vitro release of metformin HCl from these ionotropic ally-gelled SA-GG beads lasted for 12 hours and followed a zero-order model. The improved mucoadhesive beads also have good muco-adhesive properties with biological mucosal membranes and follow pH-dependent swelling.
IJCRT's Publication Details
Unique Identification Number - IJCRT2110359
Paper ID - 212771
Page Number(s) - d70-d82
Pubished in - Volume 9 | Issue 10 | October 2021
DOI (Digital Object Identifier) -
Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Navnath Bidgar, Dr.K.B.Burade, Dr.M.S.Charde, "SUSTAIN RELEASE BEHAVIOR OF METFORMIN HYDROCHLORIDE THROUGH INCORPORATION OF STOMACH AND INTESTINE SPECIFIC SODIUM ALGINATE BEADS", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.9, Issue 10, pp.d70-d82, October 2021, Available at :http://www.ijcrt.org/papers/IJCRT2110359.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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