Published Paper Details:

The present study aimed to express the worse effect of non-nutritional sweetener aspartame on streptozotocin (STZ) induced diabetic male Wistar rats. Aspartame was non-nutritional and low-calorie sugars which are nearly 200 times sweeter than table sugar sucrose.In this experiment we categorized four groups as control (C), Aspartame (ASP) (50mg/kg b.wt daily), Diabetic (D) (STZ single dose 45mg/kg b.wt) Diabetic+Aspartame (D+ASP) (STZ single dose 45mg/kg b.wt +ASP 50mg/kg b.wt daily). The blood serum concentration levels of total cholesterol (TC), triglycerides (TGs), very-low-density lipoprotein (VLDL),low-density lipoprotein (LDL) increased, and high-density lipoproteins (HDL) are decreased both in diabetic and aspartame administered rats. In this study, the serum levels of the above markers,which were highly increased in diabetes (D)and aspartame (ASP) consumed rats group when compared to control group rats. Therefore, Aspartame metabolites show negative effects on blood circulation, leading to stress-related disorders and dyslipidemia.