Published Paper Details:

The main aim of the present work was to formulate fast dissolving oral film of Glycopyrrolate. Glycopyrrolate is an anticholinergic medication with a quaternary ammonium structure. It is a potent controller of Drooling observed in children affected with clebral plasy and has low oral bioavailability. This drug also undergoes first-pass metabolism. To overcome all these problems fast dissolving oral films were prepared which helps to improve the bioavailability of drugs. Oral films dissolve fastly along with drugs and mostly all drug absorbs through oral mucosa in the systemic circulation. Oral films were prepared by the solvent casting method. Pullulan and PEG 400 were optimized by using central composite 3 factor, 2 level design based on drug release, and thickness of films. A total of thirteen batches were prepared from which batch containing 50% Pullulan, 20% PEG was found to be best. Oral films of the optimized batch were disintegrated within 14 sec and show 85.60% drug release. The optimized film was further evaluated for drug content, folding endurance, pH values, disintegration time, percent elongation and physical appearance.