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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
THERMOSENSITIVE MUCOADHESIVE IN SITU GEL FOR INTRANASAL DELIVERY OF ATOMOXETINE HCL: FORMULATION, CHARACTERIZATION, AND EVALUATION
Authors
Nikhil P. Sadamat, Yogesh N. Gavhane.
Keywords
Atomoxetine HCl, ADHD, Intra nasal, In situ gel, Poloxamer 407, Thermo sensitive, Mucoadhesive.
Abstract
In situ gels have been considered as promising drug delivery system for Atomoxetine, since they have been shown to sustain the drug release up to 7 hours. The main objective of this study was to prepare and characterize in situ gel of Atomoxetine HCl. Gels were prepared using Ploxamer 407 as thermosensitive polymer and HPMC K4M, HPMC K100 and Carbopol as mucoadhesive polymer using the cold method. Central composite experimental design was employed for the optimization of the effect of independent variables on the response (gelation temperature, mucoadhesive strength and % drug diffusion). Gels were evaluated for appearance, mucoadhesive strength, phase transition, and their performance in vitro and ex vivo using Franz diffusion cell. Acording to the findings of this research, an in situ gel of Atomoxetine HCl could be considered as a conceivable drug delivery system for treatment of ADHD.
IJCRT's Publication Details
Unique Identification Number - IJCRT2109154
Paper ID - 211714
Page Number(s) - b403-b418
Pubished in - Volume 9 | Issue 9 | September 2021
DOI (Digital Object Identifier) - http://doi.one/10.1729/Journal.28109
Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Nikhil P. Sadamat, Yogesh N. Gavhane., "THERMOSENSITIVE MUCOADHESIVE IN SITU GEL FOR INTRANASAL DELIVERY OF ATOMOXETINE HCL: FORMULATION, CHARACTERIZATION, AND EVALUATION", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.9, Issue 9, pp.b403-b418, September 2021, Available at :http://www.ijcrt.org/papers/IJCRT2109154.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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